mechanism of action Capecitabine is converted into fluorouracil by a series of enzymatic reactions. Pharmacology: Pharmacodynamics: Mechanism of Action: Capecitabine is a fluoropyrimidine carbamate derivative that was designed as an orally administered, tumor-activated and tumor-selective cytotoxic agent. Capecitabine has shown efficacy and safety when given with trastuzumab in the metastatic setting. Capecitabine is non-cytotoxic Mechanism of action 5-fluorouracil Inhibition of thymidylate synthase (potentiated by addition of leucovorin) Incorporation of fraudulent bases into DNA and RNA Raltitrexed Direct inhibitor of thymidylate synthase Capecitabine As for 5-fluorouracil Irinotecan Topoisomerase I poison Oxaliplatin

Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes’ C) colon cancer (April 2006) NICE TA100 Capecitabine alone or oxaliplatin combined with fluorouracil and folinic acid are options for adjuvant treatment following surgery for stage III (Dukes’ C) colon cancer. It is taken by mouth. One of the enzymes involved in this activation process, thymidine phosphorylase is expressed in higher concentrations in some human carcinomas compared to normal tissues, which may result in higher intra-tumor concentrations of fluorouracil. For breast cancer it is often used together with docetaxel.

Xeloda Mechanism of Action: Pharmacotherapeutic Group: Cytostatic agent. What is capecitabine (Xeloda), and how does it work (mechanism of action)?

Common side effects include abdominal pain, vomiting, diarrhea, weakness, and rashes. Capecitabine is an oral medication for treating advanced breast cancer that is resistant to combination therapy with the drugs of choice, paclitaxel ( Taxol ) and a drug from the anthracycline family of drugs, for example, doxorubicin ( … Capecitabine is non-cytotoxic in vitro.However, in vivo, it is sequentially converted to the cytotoxic moiety, 5-fluorouracil (5-FU), which is further metabolised.

Capecitabine, sold under the brand name Xeloda among others, is a chemotherapy medication used to treat breast cancer, gastric cancer and colorectal cancer. Pharmacology: Pharmacodynamics: Mechanism of Action: Capecitabine is a fluoropyrimidine carbamate derivative, which was designed as an orally administered, tumour-activated and tumour-selective cytotoxic agent.